Endocrine Abstracts

GLP-1 is a gut hormones with insulinotropic effects. GLP-1 is expressed at the hypothalamus having regulatory functions in food intake and neuroendocrine corticoadrenal axis (HPA). Energy balance and HPA have deep influence in the gonadal function of mammals. Exendin-4 (Ex4) is a potent agonist for the GLP-1 receptor.Objectives: To evaluate the effects of native GLP-1 (7–36)-NH2(GLP-1) and Ex4 in the function of the reproductive system in adulthood ...

Maternal food restriction during late pregnancy and lactation, increases the risk of glucose intolerance and metabolic diseases such as diabetes & obesity in rats. Liraglutide is a GLP-1 receptor agonists administered for treating DM2. The aim of this study was to elucidate if liraglutide given to pregnant rats may prevent the deleterious effects of malnourishment in male pups analyzed at 21 days of age.Twenty eight Sprague-Dawley pregnant rats were ...

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease characterized by excessive matrix deposition that disrupts the normal alveolar architecture and lung physiology. Glucagon-like peptide 1 (GLP1) is a gut-produced hormone with insulinotropic effects. GLP1 receptor is expressed in the lung where it is implicated in the synthesis of the protein (SPs) and lipid fractions of the surfactant. We have previously shown that the GLP1 receptor agonist, l...